MSc Thesis Defence by Justine Guidon
Master of Science in Molecular and MacroMolecular Sciences
Title : Thermodynamic Properties and Applications of Modified 尾-Cyclodextrins
Host-guest chemistry is a key area of supramolecular chemistry in which noncovalent interactions between a host and a guest molecule result in the formation of an inclusion complex. Fluorescence spectroscopy is used as a primary tool to study these interactions, as it can detect changes in emission properties upon complex formation. This work centers on modified 尾-cyclodextrins, which are macrocyclic hosts valued for their hydrophobic cavities, chemical tunability, and biocompatibility. The research is divided into three interconnected projects, each exploring different modified 尾-cyclodextrins with a focus on their inclusion properties and potential applications. The first project examines how structural differences in both host and guest molecules influence the thermodynamic properties of the inclusion process. The second project studies a 尾-cyclodextrin derivative (L12), functionalized to chelate gadolinium ions for use as an MRI contrast agent, and assesses its capacity to include guest molecules despite its bulky modifications. The third project explores 尾-cyclodextrin-grafted magnetic nanoparticles developed for pollutant capture in textile wastewater. Together, these studies provide a deeper understanding of how chemical modifications on 尾-cyclodextrins affect the inclusion behaviour and binding capability of the host. The findings support the relevance of cyclodextrin-based materials for diverse applications, including drug delivery, imaging, and environmental remediation.
August 18, 2025 at 10:00 am, in AVC 278N
Everyone is Welcome
